Leonard Amaral Selected Research

Thioridazine (Mellaril)

1/2017	Thioridazine: A Non-Antibiotic Drug Highly Effective, in Combination with First Line Anti-Tuberculosis Drugs, against Any Form of Antibiotic Resistance of Mycobacterium tuberculosis Due to Its Multi-Mechanisms of Action.
11/2016	The Anticancer Activity of the Old Neuroleptic Phenothiazine-type Drug Thioridazine.
1/2016	Thioridazine Alters the Cell-Envelope Permeability of Mycobacterium tuberculosis.
3/2014	Mechanisms by which thioridazine in combination with antibiotics cures extensively drug-resistant infections of pulmonary tuberculosis.
12/2013	The mechanism by which the phenothiazine thioridazine contributes to cure problematic drug-resistant forms of pulmonary tuberculosis: recent patents for "new use".
11/2013	Effect of thioridazine stereoisomers on the drug accumulation of mouse lymphoma and human prostate cancer cell lines in vitro.
12/2012	The added effect of thioridazine in the treatment of drug-resistant tuberculosis.
9/2012	Why and How the Old Neuroleptic Thioridazine Cures the XDR-TB Patient.
8/2012	Why and how thioridazine in combination with antibiotics to which the infective strain is resistant will cure totally drug-resistant tuberculosis.
5/2012	Why thioridazine in combination with antibiotics cures extensively drug-resistant Mycobacterium tuberculosis infections.

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Leonard Amaral Research Topics

Disease

28	Infections 01/2017 - 09/2002
19	Tuberculosis (Tuberculoses) 01/2016 - 09/2002
18	Neoplasms (Cancer) 11/2017 - 05/2003
13	Extensively Drug-Resistant Tuberculosis 01/2016 - 04/2008
10	Lymphoma (Lymphomas) 01/2016 - 06/2009
9	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 12/2013 - 09/2005
6	Pulmonary Tuberculosis 01/2017 - 03/2003
5	Bacterial Infections (Bacterial Infection) 02/2013 - 09/2003
4	Acquired Immunodeficiency Syndrome (AIDS) 03/2012 - 07/2005
2	Communicable Diseases (Infectious Diseases) 03/2017 - 05/2009
2	Colonic Neoplasms (Colon Cancer) 06/2015 - 10/2011
2	Breast Neoplasms (Breast Cancer) 05/2013 - 09/2009
2	Psychotic Disorders (Schizoaffective Disorder) 12/2011 - 07/2006
1	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2017
1	Parkinson Disease (Parkinson's Disease) 11/2017
1	Alzheimer Disease (Alzheimer's Disease) 11/2017
1	Adenocarcinoma 06/2015
1	Prostatic Neoplasms (Prostate Cancer) 11/2013
1	Carcinoma (Carcinomatosis) 10/2011
1	Weight Gain 06/2010
1	Salmonella Infections (Salmonellosis) 02/2010
1	Sudden Death 07/2006
1	Cross Infection (Nosocomial Infection) 11/2004
1	Reinfection 11/2004
1	Urinary Tract Infections (Urinary Tract Infection) 09/2003
1	T-Cell Lymphoma (Lymphoma, T Cell) 05/2003
1	Virus Diseases (Viral Diseases) 05/2003
1	Staphylococcal Infections 09/2002

Drug/Important Bio-Agent (IBA)

25	Pharmaceutical PreparationsIBA 11/2016 - 09/2002
24	Anti-Bacterial Agents (Antibiotics)IBA 03/2017 - 09/2002
23	Thioridazine (Mellaril)FDA LinkGeneric 01/2017 - 11/2004
12	Antipsychotic Agents (Antipsychotics)IBA 11/2016 - 11/2004
10	phenothiazineIBA 06/2015 - 03/2003
8	PhenothiazinesIBA 11/2017 - 09/2003
8	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 11/2016 - 06/2009
5	Ethidium (Ethidium Bromide)IBA 01/2016 - 10/2009
4	Rhodamine 123IBA 01/2016 - 10/2009
4	Rifampin (Rifampicin)FDA LinkGeneric 01/2012 - 09/2005
3	Adenosine Triphosphate (ATP)IBA 01/2016 - 06/2009
3	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2015 - 12/2010
3	Isoniazid (Ftivazide)FDA LinkGeneric 06/2012 - 09/2010
3	ATP-Binding Cassette Transporters (ABC Transporters)IBA 03/2012 - 06/2009
3	HydantoinsIBA 03/2012 - 12/2010
3	Chlorpromazine (Thorazine)FDA Link 12/2011 - 11/2004
3	Verapamil (Calan)FDA LinkGeneric 12/2009 - 05/2003
2	EcdysteroidsIBA 01/2015 - 12/2013
2	1,3- dimethyl- 1,3- bis(4- fluorophenyl)- 1,3- bis(3- (1- (4- butypiperazinyl))propyl)disiloxaneIBA 05/2013 - 05/2009
2	Proteins (Proteins, Gene)FDA Link 02/2010 - 03/2005
2	EnzymesIBA 05/2009 - 08/2004
2	Reserpine (Serpasil)FDA Link 01/2008 - 09/2002
1	Cytotoxins (Cytolysins)IBA 11/2016
1	CarbocyaninesIBA 01/2016
1	3,3'-diethyloxacarbocyanineIBA 01/2016
1	Coloring Agents (Dyes)IBA 01/2016
1	Fluorescent Dyes (Fluorescent Probes)IBA 01/2016
1	Ion Channels (Ion Channel)IBA 01/2016
1	Vincristine (Oncovin)FDA LinkGeneric 01/2015
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2015
1	Cisplatin (Platino)FDA LinkGeneric 01/2015
1	Ecdysterone (20 Hydroxyecdysone)IBA 01/2015
1	DioxolanesIBA 12/2013
1	BromidesIBA 11/2013
1	Neoplasm Antigens (Tumor Antigens)IBA 05/2013
1	1,3- dimethyl- 1,3- (4- fluorophenyl)- 1,3- (3- butyl- (1- piperazinyl)propyl)- 1,3- disiloxaneIBA 05/2013
1	MorpholinosIBA 05/2013
1	Epstein-Barr virus early antigenIBA 05/2013
1	disiloxaneIBA 05/2013
1	1,3- dimethyl- 1,3- p- fluorophenyl- 1,3- (3- morpholinopropyl)- 1,3- disiloxaneIBA 05/2013
1	Antineoplastic Agents (Antineoplastics)IBA 12/2011
1	Biological ProductsIBA 12/2010
1	Pyrazinamide FDA LinkGeneric 09/2010
1	Azithromycin (Zithromax)FDA LinkGeneric 12/2009
1	Clarithromycin (Biaxin)FDA LinkGeneric 12/2009
1	MacrolidesIBA 12/2009
1	Disinfectants (Biocides)IBA 10/2009
1	Serine Proteases (Serine Protease)IBA 09/2009
1	ethyl N- allyl- N- (2- methyl- 3- (4- (4- amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonateIBA 09/2009
1	camostatIBA 09/2009
1	Ouabain (G Strophanthin)IBA 01/2008
1	Diclofenac (SR 38)FDA LinkGeneric 09/2007
1	Tetracycline (Achromycin)FDA LinkGeneric 07/2007
1	Tuberculin (PPD)IBA 03/2005
1	Vancomycin FDA LinkGeneric 11/2004
1	InterleukinsIBA 08/2004
1	InterferonsIBA 08/2004
1	ImmunosorbentsIBA 08/2004
1	Interleukin-4 (Interleukin 4)IBA 08/2004
1	Sepharose (Agarose)IBA 09/2003
1	Promethazine (Promet)FDA LinkGeneric 09/2003
1	Plant ExtractsIBA 05/2003

Therapy/Procedure

30	Therapeutics 03/2017 - 03/2003
8	Drug Therapy (Chemotherapy) 11/2017 - 05/2003
1	Chemoprevention 05/2013
1	Oral Administration 09/2010